Vitamin D defends against infections in skin wounds

According to new experiments conducted by researchers at Oregon State University (OSU), vitamin D can be of great help in preventing infections, particularly those that can arise as a result of injuries to the skin.

According to the researchers, in fact, the treatment with vitamin D greatly reduces the number of pathogens in wounds by regulating an important antimicrobial peptide in the body. In the study, published in the Journal of Steroid Biochemistry and Molecular Biology, is in fact described as vitamin D, present in a few foods including beef liver, cheese, egg yolks and fatty fish meat, promotes the production of catelicidin (CAMP), an antimicrobial peptide made of immune cells and cells that act as a barrier against infection.

The same gene that encodes catelicidin is present in humans and other primates. In other mammals, including mice, there is a gene that resembles it but is not activated by vitamin D. In fact, researchers carried out experiments on mice by grafting the human CAMP gene into them: rodents showed greater resistance to intestinal and staphylococcal infections on the skin.

Adrian Gombart, a scientist at OSU, and one of the authors of the study, says in the press release: “With our mouse model, we have shown that treating a skin wound infected with S. aureus with the bioactive form of vitamin D significantly reduced the number of bacteria in the wound.”

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