DNA mutations accelerate biological age and aging

Research suggests that DNA changes can be one of the causes of serious age-related diseases, including heart disease and other age-related diseases.

Researchers have analyzed somatic mutations, that is DNA alterations that usually affect the work done by stem cells within the blood. According to the researchers, these very mutations, and the pathologies they can cause, accelerate the biological age of the individual regardless of the chronological age.

The biological age and the age that can be attributed to a person depending on his or her physical condition in relation to various reference standards and that can be unrelated to age.

The study was conducted by researchers from the University of Edinburgh and the University of Glasgow. The researchers analyzed more than 1000 elderly people aged between 80 and 90 years.

The results showed that 6% of the participants with somatic mutations were almost four years older than the biological age of the participants without mutations.

The study was published in Current Biology.

Links/Sources:

https://www.ed.ac.uk/news/2019/dna-changes-accelerate-body-s-ageing-process

https://www.cell.com/current-biology/fulltext/S0960-9822(19)30856-5

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